The Center for Structural Biology is composed of a core group of six research laboratories located in Cook Hall on the Evanston Campus of Northwestern University. The center also includes a number of additional faculty in the Department of Molecular Biosciences, the Structural Biology Center at the Advanced Photon Source of the Argonne National Laboratory, and the Molecular Biophysics Program.

The Center for Structural Biology brings together research groups with an interest in structural biology, particularly molecular biophysics and biochemistry. The Center houses several research facilities that are crucial in modern biological macromolecules research. Additionally, the Center helps to promote and disseminate knowledge in Structural Biology through seminars, clubs, and meetings.

Two major research facilities are directly managed by members of the Center for Structural Biology: the Keck Biophysics Facility and the Structural Biology Facility. Additionally, members of the Center have a large involvement in the NMR Facility.